Novo Nordisk's Wegovy Outshines Eli Lilly's Tirzepatide In Reducing Risk Of Heart Attack, Stroke And Death

Novo Nordisk A/S (NYSE:NVO) on Sunday presented data from the STEER real-world study of evidence gathered from actual patient experiences at the European Society of Cardiology (ESC) Congress 2025.

The STEER study investigated the risk of major adverse cardiovascular events (MACE) with Wegovy (semaglutide) 2.4 mg compared with tirzepatide treatment in people with overweight or obesity and established cardiovascular disease (CVD) without diabetes.

Compared with Eli Lilly and Co.’s (NYSE:LLY) tirzepatide (Zepbound, Mounjaro), Wegovy showed a significant 57% greater risk reduction for heart attack, stroke, and cardiovascular-related death or death from any cause, in people with overweight or obesity and CVD, while on treatment with no treatment gaps of more than 30 days. 

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